• Therapeutic options targeting intrahepatic resistance are ve

  2021-03-10

  

  Therapeutic options targeting intrahepatic resistance are very limited. Theoretically, the NO-cGMP pathway may be influenced at several sites. Yet, most strategies did not reach clinical practice or yielded disappointing results, such as activators of soluble guanylate cyclase [14], NO releasing der

• proton pump inhibitors In Murray Darling rainbowfish confirm

  2021-03-10

  

  In Murray–Darling rainbowfish, confirming the expected in vivo effects of androgenic progestins could be achieved using short-term exposures and determining expression profiles for androgen-responsive genes, or in longer term exposures by monitoring fecundity or the development of male secondary sex

• River sand was graded in accordance

  2021-03-10

  

  River sand was graded in accordance with ASTM C778 [47] (see Table 2). The graded sand had a water Naphthoquine phosphate mg of 1.00%, fineness modulus of 3.49 and specific gravity of 2350kg/m3. A polycarboxylate based superplasticizer called ZP with pH of 7±1 and specific gravity of 1.1±0.02 was a

• Methods br Results First we compared

  2021-03-10

  

  Methods Results First, we compared Aβ plaque number, Aβ concentration, and neurobehavior functions between naive APP/PS1 and APP/PS1xEP1−/− mice. Significantly lower Aβ burden in APP/PS1xEP1−/− mice was evidenced by fewer plaques in the hippocampal area and a lower concentration of soluble Aβ42

• is one of the few parasites that can be encysted

  2021-03-10

  

  is one of the few parasites that can be encysted and excysted and we tested the localization and role of HA-tagged gEno in both differentiations, using a recently developed integrated vector that introduces a C-terminal triple HA tag under the selection marker puromycin . The localization of HA-tagg

• br Materials and methods br Results discussion br

  2021-03-10

  

  Materials and methods Results + discussion Conclusions We have demonstrated the systematic optimization of the functional folding of a CF synthesized GPCR. The approach addresses central issues relevant for many membrane proteins such as disulfide bridge formation, proper hydrophobic enviro

• Compared with qualitative analysis by Kalyankar et al less

  2021-03-10

  

  Compared with qualitative analysis by Kalyankar et al. (2013), less sequences were identified in iTRAQ-labelled analysis. It is not surprising with the finding that each of the identified peptide includes the sequence in every sampling point. Glu(51)-Tyr(52) of αs2-casein was observed to have been c

• br Introduction Cancer related inflammation is associated wi

  2021-03-10

  

  Introduction Cancer related inflammation is associated with poor prognosis and reduced survival in numerous human malignancies. Expansion of myeloid derived immune aurora a receptor in response to tumor-secreted factors largely contributes to the heightened systemic and intra-tumoral inflammator

• Although CCR expression clearly identifies MBC precursors wi

  2021-03-10

  

  Although CCR6 expression clearly identifies MBC precursors within the GC, we found that the expression of this chemokine receptor by responding Ciprofibrate was not required for MBC differentiation and had no detectable impact on the GC subsets analyzed in this study. Although this is in agreement

• EBI and its ligand s EBI was found in a

  2021-03-10

  

  EBI2 and its ligand(s) EBI2 was found in a screen of upregulated genes in human B cells upon infection with EBV [1]. EBI2 is a G-protein (Gαi type) coupled receptor [2] but as long as 18 years after its discovery the nature of its ligand remained undisclosed. With the help of transfected cell lines

• br APC C Uses a Dynamic Cullin RING Mechanism

  2021-03-10

  

  APC/C Uses a Dynamic Cullin–RING Mechanism to Elongate Polyubiquitin Chains Human APC/C generates Lys11-linked poly-Ub chains through an entirely different mechanism, via the distinctive E2 enzyme, UBE2S 30, 31, 32. Although APC2 and APC11 are necessary and sufficient to activate UBE2S, the mecha

• Despite the important agronomic traits regulated by SUMO mos

  2021-03-10

  

  Despite the important agronomic traits regulated by SUMO, most research studies on SUMOylation have been mainly limited to model plants, such as Arabidopsis and rice (Wang et al., 2011), due to the lack of molecular tools specific to other economically relevant plants. On the other hand, plants harb

• Common enzyme quantitative methods include enzyme linked imm

  2021-03-09

  

  Common enzyme quantitative methods include enzyme-linked immunosorbent assay [,] (ELISA), chemiluminescence (CLIA) [, , ] and immunochromatography []. The advantages of ELISA are cost reduction and automation, but non-specific reaction caused by HOOK effect, false positive caused by cross-contaminat

• The involvement of FOXO and STAT in DNA

  2021-03-09

  

  The involvement of FOXO3 and STAT5 in DNA-PKcs and Novobiocin Sodium synthesis IV has not been reported before, and the search by the ECR browser (http://ecrbrowser.decode.org) revealed that 1kb of the 5′ promoter of DNA-PKcs possesses 4 STAT (−908bp to −901bp, −676bp to −656bp, −533bp to −526bp and

• br Results and discussion br Conclusion Novel

  2021-03-09

  

  Results and discussion Conclusion Novel and selective aziridine-based inhibitors for the Leishmania mexicana protease LmCBP2.8 were discovered. Compounds 7d (Ki = 0.8 μM), 9d (Ki = 1.36 μM), 12d (Ki = 0.77 μM), 14d (Ki = 0.9 μM) and 18 (Ki = 0.441 μM) showed the highest potency and selectivity

15626 records 681/1042 page Previous Next First page 上5页 681682683684685 下5页 Last page